Increased Mitotic Rate Coincident with Transient Telomere Lengthening Resulting from Pim‐1 Overexpression in Cardiac Progenitor Cells

Abstract excerpt

Cardiac regeneration following myocardial infarction rests with the potential of c-kit+ cardiac progenitor cells (CPCs) to repopulate damaged myocardium. The ability of CPCs to reconstitute the heart is restricted by patient age and disease progression. Increasing CPC proliferation, telomere length, and survival will improve the ability of autologous CPCs to be successful in myocardial regeneration. Prior studies...

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