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Article

Stress-induced Premature Senescence in hTERT-expressing Ataxia Telangiectasia Fibroblasts

1 Jan 2004

Abstract excerpt

In addition to replicative senescence, normal diploid fibroblasts undergo stress-induced premature senescence (SIPS) in response to DNA damage caused by oxidative stress or ionizing radiation (IR). SIPS is not prevented by telomere elongation, indicating that, unlike replicative senescence, it is triggered by nonspecific genome-wide DNA damage rather than by telomere shortening. ATM, the product of the gene...

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PMID: 14570874
DOI: 10.1074/jbc.m309457200

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