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Article

Accelerated cellular senescence as underlying mechanism for functionally impaired bone marrow-derived progenitor cells in ischemic heart disease.

Atherosclerosis - 1 May 2017

Nollet Evelien, Hoymans Vicky Y, Rodrigus Inez R, De Bock Dina, Dom Marc, Van Hoof Viviane O M, Vrints Christiaan J, Van Craenenbroeck Emeline M

Abstract excerpt

BACKGROUND AND AIMS: Bone marrow (BM)-derived progenitor cells are functionally impaired in patients with ischemic heart disease (IHD), thereby hampering the outcome of autologous stem cell therapy. In search for underlying mechanisms for this BM dysfunction, accelerated cellular senescence was explored. METHODS: We analysed telomere length of BM-derived mononuclear cells (MNC) by MMqPCR in patients with coronary...

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PMID: 28434530
DOI: 10.1016/j.atherosclerosis.2017.03.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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