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Telomerase Is Essential for Zebrafish Heart Regeneration

28 Aug 2015

Abstract excerpt

After myocardial infarction in humans, lost cardiomyocytes are replaced by an irreversible fibrotic scar. In contrast, zebrafish hearts efficiently regenerate after injury. Complete regeneration of the zebrafish heart is driven by the strong proliferation response of its cardiomyocytes to injury. Here we show that, after cardiac injury in zebrafish, telomerase becomes hyperactivated, and telomeres elongate...

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PMID: 26321646
DOI: 10.1016/j.celrep.2015.07.064

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