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Article

Identification of New Tumor Suppressor Genes in Triple-Negative Breast Cancer

19 Jul 2017

Abstract excerpt

Abstract Although genomic sequencing has provided a better understating of the genetic landmarks in triple-negative breast cancer (TNBC), functional validation of candidate cancer genes (CCG) remains unsolved. In this study, we used a transposon mutagenesis strategy based on a two-step sleeping beauty (SB) forward genetic screen to identify and validate new tumor suppressors (TS) in this disease. We generated 120...

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PMID: 28724549
DOI: 10.1158/0008-5472.can-17-0785

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