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Article

FOXO3 longevity interactome on chromosome 6.

Aging cell - 1 Oct 2017

Donlon Timothy A, Morris Brian J, Chen Randi, Masaki Kamal H, Allsopp Richard C, Willcox D Craig, Elliott Ayako, Willcox Bradley J

Abstract excerpt

FOXO3 has been implicated in longevity in multiple populations. By DNA sequencing in long-lived individuals, we identified all single nucleotide polymorphisms (SNPs) in FOXO3 and showed 41 were associated with longevity. Thirteen of these had predicted alterations in transcription factor binding sites. Those SNPs appeared to be in physical contact, via RNA polymerase II binding chromatin looping, with sites in...

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Source

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Identifiers

PMID: 28722347
DOI: 10.1111/acel.12625
PMCID: PMC5595686

Genes

FOXO3
CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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