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Article

FOXO in the hole: leveraging GWAS for outcome and function.

Cell - 26 Sept 2013

Gregersen Peter K, Manjarrez-Orduño Nataly

Abstract excerpt

GWAS studies of autoimmune disorders have yielded hundreds of replicated associations, but moving from genetic association to functional studies with potential clinical relevance is a challenge. Leveraging GWAS data, Lee et al. now identify FOXO3 activity as predictive of disease severity in Crohn's disease and rheumatoid arthritis as well as malaria, likely by acting through regulation of cytokine production in...

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Share to Forkhead Box Protein O3
Share to Arthritis, Rheumatoid
Share to Crohn Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Transcription Factors

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Share to Malaria, Falciparum

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 24074853
DOI: 10.1016/j.cell.2013.08.050

Genes

FOXO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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