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Article

Functional consequences of a novel variant of PCSK1.

PloS one - 1 Jan 2013

Pickett Lindsay A, Yourshaw Michael, Albornoz Valeria, Chen Zijun, Solorzano-Vargas R Sergio, Nelson Stanley F, Martín Martín G, Lindberg Iris

Abstract excerpt

BACKGROUND: Common single nucleotide polymorphisms (SNPs) in proprotein convertase subtilisin/kexin type 1 with modest effects on PC1/3 in vitro have been associated with obesity in five genome-wide association studies and with diabetes in one genome-wide association study. We here present a novel SNP and compare its biosynthesis, secretion and catalytic activity to wild-type enzyme and to SNPs that have been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 23383060
DOI: 10.1371/journal.pone.0055065
PMCID: PMC3557230

Genes

PCSK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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