Article
Exome arrays capture polygenic rare variant contributions to schizophrenia.
Human molecular genetics - 1 Mar 2016
Richards A L, Leonenko G, Walters J T, Kavanagh D H, Rees E G, Evans A, Chambert K D, Moran J L, Goldstein J, Neale B M, McCarroll S A, Pocklington A J, Holmans P A, Owen M J, O'Donovan M C
Abstract excerpt
Schizophrenia is a highly heritable disorder. Genome-wide association studies based largely on common alleles have identified over 100 schizophrenia risk loci, but it is also evident from studies of copy number variants (CNVs) and from exome-sequencing studies that rare alleles are also involved. Full characterization of the contribution of rare alleles to the disorder awaits the deployment of sequencing...
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