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Article

Loss-of-function variants in schizophrenia risk and SETD1A as a candidate susceptibility gene.

Neuron - 21 May 2014

Takata Atsushi, Xu Bin, Ionita-Laza Iuliana, Roos J Louw, Gogos Joseph A, Karayiorgou Maria

Abstract excerpt

Loss-of-function (LOF) (i.e., nonsense, splice site, and frameshift) variants that lead to disruption of gene function are likely to contribute to the etiology of neuropsychiatric disorders. Here, we perform a systematic investigation of the role of both de novo and inherited LOF variants in schizophrenia using exome sequencing data from 231 case and 34 control trios. We identify two de novo LOF variants in the...

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Identifiers

PMID: 24853937
DOI: 10.1016/j.neuron.2014.04.043
PMCID: PMC4387883

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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