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Article

The Trypanosoma brucei dihydroxyacetonephosphate acyltransferase TbDAT is dispensable for normal growth but important for synthesis of ether glycerophospholipids.

PloS one - 1 Jan 2017

Zufferey Rachel, Pirani Karim, Cheung-See-Kit Melanie, Lee Sungsu, Williams Tyler A, Chen Daniel G, Hossain Md Faruk

Abstract excerpt

Glycerophospholipids are the most abundant constituents of biological membranes in Trypanosoma brucei, which causes sleeping sickness in humans and nagana in cattle. They are essential cellular components that fulfill various important functions beyond their structural role in biological membranes such as in signal transduction, regulation of membrane trafficking or control of cell cycle progression. Our previous...

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PMID: 28715456
DOI: 10.1371/journal.pone.0181432
PMCID: PMC5513551

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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