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Article

Division and Adaptation to Host Environment of Apicomplexan Parasites Depend on Apicoplast Lipid Metabolic Plasticity and Host Organelle Remodeling.

Cell reports - 17 Mar 2020

Amiar Souad, Katris Nicholas J, Berry Laurence, Dass Sheena, Duley Samuel, Arnold Christophe-Sebastien, Shears Melanie J, Brunet Camille, Touquet Bastien, McFadden Geoffrey I, Yamaryo-Botté Yoshiki, Botté Cyrille Y

Abstract excerpt

Apicomplexan parasites are unicellular eukaryotic pathogens that must obtain and combine lipids from both host cell scavenging and de novo synthesis to maintain parasite propagation and survival within their human host. Major questions on the role and regulation of each lipid source upon fluctuating host nutritional conditions remain unanswered. Characterization of an apicoplast acyltransferase, TgATS2, shows...

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PMID: 32187549
DOI: 10.1016/j.celrep.2020.02.072

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