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Article

The Glycerol-3-Phosphate Acyltransferase TbGAT is Dispensable for Viability and the Synthesis of Glycerolipids in Trypanosoma brucei.

The Journal of eukaryotic microbiology - 1 Sept 2016

Patel Nipul, Pirani Karim A, Zhu Tongtong, Cheung-See-Kit Melanie, Lee Sungsu, Chen Daniel G, Zufferey Rachel

Abstract excerpt

Glycerolipids are the main constituents of biological membranes in Trypanosoma brucei, which causes sleeping sickness in humans. Importantly, they occur as a structural component of the glycosylphosphatidylinositol lipid anchor of the abundant cell surface glycoproteins procyclin in procyclic forms and variant surface glycoprotein in bloodstream form, that play crucial roles for the development of the parasite in...

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PMID: 26909872
DOI: 10.1111/jeu.12309
PMCID: PMC4993694

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The Glycerol-3-Phosphate Acyltransferase TbGAT is Dispensable for Viability and the Synthesis of Glycerolipids in Trypanosoma brucei.PMID 26909872Read ↗

The Trypanosoma brucei dihydroxyacetonephosphate acyltransferase TbDAT is dispensable for normal growth but important for synthesis of ether glycerophospholipids.Semantic proximity Read ↗

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