Article
The intracellular parasite Toxoplasma gondii depends on the synthesis of long-chain and very long-chain unsaturated fatty acids not supplied by the host cell.
Molecular microbiology - 1 Jul 2015
Ramakrishnan Srinivasan, Docampo Melissa D, MacRae James I, Ralton Julie E, Rupasinghe Thusitha, McConville Malcolm J, Striepen Boris
Abstract excerpt
Apicomplexa are parasitic protozoa that cause important human diseases including malaria, cryptosporidiosis and toxoplasmosis. The replication of these parasites within their target host cell is dependent on both salvage as well as de novo synthesis of fatty acids. In Toxoplasma gondii, fatty acid synthesis via the apicoplast-localized FASII is essential for pathogenesis, while the role of two other fatty acid...
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