Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic and chemical evaluation of Trypanosoma brucei oleate desaturase as a candidate drug target.

PloS one - 6 Dec 2010

Alloatti Andrés, Gupta Shreedhara, Gualdrón-López Melisa, Igoillo-Esteve Mariana, Nguewa Paul A, Deumer Gladys, Wallemacq Pierre, Altabe Silvia G, Michels Paul A M, Uttaro Antonio D

Abstract excerpt

BACKGROUND: Trypanosomes can synthesize polyunsaturated fatty acids. Previously, we have shown that they possess stearoyl-CoA desaturase (SCD) and oleate desaturase (OD) to convert stearate (C18) into oleate (C18:1) and linoleate (C18:2), respectively. Here we examine if OD is essential to these...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chemistry, Pharmaceutical
Share to Fatty Acid Desaturases
Share to Heme

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Linoleic Acid

Share to Oleic Acid

Share to Oxidoreductases Acting on CH-CH Group Donors

Share to Stearoyl-CoA Desaturase

Share to Trypanosoma brucei brucei

Source

Open in PubMed Open full text

Identifiers

PMID: 21151902
DOI: 10.1371/journal.pone.0014239
PMCID: PMC2997783

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21151902-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic and chemical evaluation of Trypanosoma brucei oleate desaturase as a candidate drug target.PMID 21151902Read ↗

Exploring the activity and the essentiality of the putative Δ6-desaturase in the procyclic and bloodstream forms of <i>Trypanosoma brucei</i>Semantic proximity Read ↗

Lipid and fatty acid metabolism in trypanosomatidsSemantic proximity Read ↗

The intracellular parasite Toxoplasma gondii depends on the synthesis of long-chain and very long-chain unsaturated fatty acids not supplied by the host cell.Semantic proximity Read ↗

The Trypanosoma brucei dihydroxyacetonephosphate acyltransferase TbDAT is dispensable for normal growth but important for synthesis of ether glycerophospholipids.Semantic proximity Read ↗

A <i>Trypanosoma brucei</i> ORFeome-based Gain-of-Function Library reveals novel genes associated with melarsoprol resistanceSemantic proximity Read ↗

The fatty acid oleate is required for innate immune activation and pathogen defense in Caenorhabditis elegansSemantic proximity Read ↗

Long-chain unsaturated fatty acids are involved in the viability and itraconazole susceptibility of Aspergillus fumigatus.Semantic proximity Read ↗

Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model.Semantic proximity Read ↗

Unique Mechanism of Action of the Thiourea Drug Isoxyl on Mycobacterium tuberculosisSemantic proximity Read ↗

Molecular target analysis of stearoyl-CoA desaturase genes of protozoan parasites.Semantic proximity Read ↗

The antiepileptic drug valproic acid and other medium-chain fatty acids acutely reduce phosphoinositide levels independently of inositol in Dictyostelium.Semantic proximity Read ↗

Targeting Trypanothione Metabolism in Trypanosomatid Human ParasitesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.