Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Host cell lipids control cholesteryl ester synthesis and storage in intracellular Toxoplasma.

Cellular microbiology - 1 Jun 2005

Nishikawa Yoshifumi, Quittnat Friederike, Stedman Timothy T, Voelker Dennis R, Choi Jae-Yeon, Zahn Matt, Yang Mei, Pypaert Marc, Joiner Keith A, Coppens Isabelle

Abstract excerpt

The intracellular protozoan Toxoplasma gondii lacks a de novo mechanism for cholesterol synthesis and therefore must scavenge this essential lipid from the host environment. In this study, we demonstrated that T. gondii diverts cholesterol from low-density lipoproteins for cholesteryl ester synthesis and storage in lipid bodies. We identified and characterized two isoforms of acyl-CoA:cholesterol acyltransferase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol Esters
Share to Cricetulus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum

Share to Isoenzymes

Share to Lipids

Share to Microscopy, Immunoelectron

Share to Palmitates

Share to Toxoplasma

Source

Identifiers

PMID: 15888087
DOI: 10.1111/j.1462-5822.2005.00518.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Host cell lipids control cholesteryl ester synthesis and storage in intracellular Toxoplasma.PMID 15888087Read ↗

Toxoplasma acyl-CoA synthetase TgACS3 is crucial to channel host fatty acids in lipid droplets and for parasite propagationSemantic proximity Read ↗

Host lipid droplets: An important source of lipids salvaged by the intracellular parasite Toxoplasma gondiiSemantic proximity Read ↗

The coccidian parasites Toxoplasma and Neospora dysregulate mammalian lipid droplet biogenesisSemantic proximity Read ↗

The intracellular parasite Toxoplasma gondii depends on the synthesis of long-chain and very long-chain unsaturated fatty acids not supplied by the host cell.Semantic proximity Read ↗

The acyl-CoA synthetase Tg ACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditionsSemantic proximity Read ↗

An endoplasmic reticulum localized acetyl-CoA transporter is required for efficient fatty acid synthesis in Toxoplasma gondiiSemantic proximity Read ↗

Toxoplasma gondii exploits host low-density lipoprotein receptor-mediated endocytosis for cholesterol acquisition.Semantic proximity Read ↗

Synthesis versus Salvage of Ester- and Ether-linked Phosphatidylethanolamine in the Intracellular Protozoan Pathogen Toxoplasma gondiiSemantic proximity Read ↗

Synthesis vs. salvage of ester- and ether-linked phosphatidylethanolamine in the intracellular protozoan pathogen Toxoplasma gondiiSemantic proximity Read ↗

Division and adaptation to host nutritional environment of apicomplexan parasites depend on apicoplast lipid metabolic plasticity and host organelles remodellingSemantic proximity Read ↗

<i>Toxoplasma gondii</i> Fatty Acid Elongases are Important for Virulence and PersistenceSemantic proximity Read ↗

Division and Adaptation to Host Environment of Apicomplexan Parasites Depend on Apicoplast Lipid Metabolic Plasticity and Host Organelle Remodeling.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.