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Article

The essential role of TAp73 in bortezomib-induced apoptosis in p53-deficient colorectal cancer cells.

Scientific reports - 14 Jul 2017

Dabiri Yasamin, Kalman Sara, Gürth Clara-Marie, Kim Jee Young, Mayer Viola, Cheng Xinlai

Abstract excerpt

Mutations in the tumor suppressor p53 are among the most highly occurring events in colorectal cancer (CRC). Such mutations have been shown to influence the sensitivity of cancer cells to chemotherapeutic agents. However their impact on the efficacy of the proteasomal inhibitor bortezomib remains controversial. We thus re-evaluated the toxicity of bortezomib in the CRC cell lines HCT116 wt (wild-type) and its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28710427
DOI: 10.1038/s41598-017-05813-z
PMCID: PMC5511205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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