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Article

Chemosensitivity linked to p73 function.

Cancer cell - 1 Apr 2003

Irwin Meredith S, Kondo Keiichi, Marin Maria Carmen, Cheng Lynn S, Hahn William C, Kaelin William G

Abstract excerpt

Most chemotherapeutic agents induce DNA damage, leading to p53 accumulation and apoptosis. The factors that determine chemosensitivity in p53-defective tumor cells are poorly understood. We found that the p53 family member p73 is induced by a wide variety of chemotherapeutic drugs. Blocking p73 function with a dominant-negative mutant, siRNA, or homologous recombination led to chemoresistance of human tumor cells...

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Share to Drug Resistance, Neoplasm
Share to Embryo, Mammalian
Share to Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to In Situ Nick-End Labeling

Share to RNA, Small Interfering

Share to Tumor Protein p73

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Source

Identifiers

PMID: 12726865
DOI: 10.1016/s1535-6108(03)00078-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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