Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cancer cell sensitivity to bortezomib is associated with survivin expression and p53 status but not cancer cell types

22 Jan 2010

Abstract excerpt

BACKGROUND: Survivin is known playing a role in drug resistance. However, its role in bortezomib-mediated inhibition of growth and induction of apoptosis is unclear. There are conflicting reports for the effect of bortezomib on survivin expression, which lacks of a plausible explanation. METHODS: In this study, we tested cancer cells with both p53 wild type and mutant/null background for the relationship of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Cell death mechanisms and regulation
Share to Protein Kinase Regulation and GTPase Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20096120
DOI: 10.1186/1756-9966-29-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cancer cell sensitivity to bortezomib is associated with survivin expression and p53 status but not cancer cell typesPMID 20096120Read ↗

Insights into apoptosis mechanisms induced by DNA-damaging agents in Burkitt's lymphoma cells.Semantic proximity Read ↗

Knockdown of caspase-activated DNase and B-cell lymphoma 2 inhibits cell proliferation and drug resistance in TP53-mutant multiple myeloma.Semantic proximity Read ↗

Investigations of survivin: the past, present and futureSemantic proximity Read ↗

Survivin splice variants regulate the balance between proliferation and cell death.Semantic proximity Read ↗

Apoptosis in Drug Response.Semantic proximity Read ↗

Survivin Small Molecules Inhibitors: Recent Advances and ChallengesSemantic proximity Read ↗

Survivin and Tumorigenesis: Molecular Mechanisms and Therapeutic StrategiesSemantic proximity Read ↗

Survivin as a Therapeutic Target for the Treatment of Human CancerSemantic proximity Read ↗

The Role of Survivin for Radiation Oncology: Moving Beyond Apoptosis InhibitionSemantic proximity Read ↗

Recent Advances on Small-Molecule Survivin InhibitorsSemantic proximity Read ↗

Survivin as a target for new anticancer interventions.Semantic proximity Read ↗

Decreased sensitivity of 17p-deleted chronic lymphocytic leukemia cells to a small molecule BCL-2 antagonist ABT-737.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.