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IgA-deficient humans exhibit gut microbiota dysbiosis despite secretion of compensatory IgM

19 Sept 2019

Abstract excerpt

Immunoglobulin A is the dominant antibody isotype found in mucosal secretions and enforces host-microbiota symbiosis in mice, yet selective IgA-deficiency (sIgAd) in humans is often described as asymptomatic. Here, we determined the effects of IgA deficiency on human gut microbiota composition and evaluated the possibility that mucosal secretion of IgM can compensate for a lack of secretory IgA. We used 16S rRNA...

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PMID: 31537840
DOI: 10.1038/s41598-019-49923-2

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