Article

IgA-deficient humans exhibit gut microbiota dysbiosis despite production of compensatory IgM

2018-10-22

Abstract excerpt

<h4>ABSTRACT</h4> Immunoglobulin A is the dominant antibody isotype found in mucosal secretions and enforces host-microbiota symbiosis in mice, yet selective IgA-deficiency (sIgAd) is the most common primary immunodeficiency in humans and is often described as asymptomatic. Here, we determined the effects of IgA deficiency on human gut microbiota composition and evaluated the possibility that secretion of IgM can...

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Literature Corpus work: 2889d331-1f0d-59e3-9a98-caed3f0c4850
DOI: 10.1101/446724

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