Article
Epigenetic Changes of the ESR1 Gene in Breast Tissue of Healthy Women: A Missing Link with Breast Cancer Risk Factors?
Genetic testing and molecular biomarkers - 1 Aug 2017
Daraei Abdolreza, Izadi Pantea, Khorasani Ghasemali, Nafissi Nahid, Naghizadeh Mohammad Mehdi, Younosi Nasim, Meysamie Alipasha, Mansoori Yaser, Bastami Milad, Tavakkoly-Bazzaz Javad
Abstract excerpt
BACKGROUND: Reproductive history and obesity are among the well-recognized risk factors in the development of breast cancer, which are partially mediated by the increased exposure of breast tissues to estrogens. However, only a few studies have investigated the link between these risk factors and the pattern of methylation signatures in the breast tissue of healthy women. The role of the estrogen receptor 1...
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