Article
A candidate CpG SNP approach identifies a breast cancer associated ESR1-SNP.
International journal of cancer - 1 Oct 2011
Harlid Sophia, Ivarsson Malin I L, Butt Salma, Hussain Shehnaz, Grzybowska Ewa, Eyfjörd Jorunn Erla, Lenner Per, Försti Asta, Hemminki Kari, Manjer Jonas, Dillner Joakim, Carlson Joyce
Abstract excerpt
Altered DNA methylation is often seen in malignant cells, potentially contributing to carcinogenesis by suppressing gene expression. We hypothesized that heritable methylation potential might be a risk factor for breast cancer and evaluated possible association with breast cancer for single nucleotide polymorphisms (SNPs) either involving CpG sequences in extended 5'-regulatory regions of candidate genes (ESR1,...
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