Body Mass Index Is Associated with Gene Methylation in Estrogen Receptor–Positive Breast Tumors

Abstract excerpt

BACKGROUND: Although obesity is associated with breast cancer incidence and prognosis, the underlying mechanisms are poorly understood. Identification of obesity-associated epigenetic changes in breast tissue may advance mechanistic understanding of breast cancer initiation and progression. The goal of this study, therefore, was to investigate associations between obesity and gene methylation in breast tumors....

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