Article
Association of PvuII and XbaI polymorphisms on estrogen receptor alpha (ESR1) gene to changes into serum lipid profile of post-menopausal women: Effects of aging, body mass index and breast cancer incidence.
PloS one - 1 Jan 2017
Gomes-Rochette Neuza Felix, Souza Letícia Soncini, Tommasi Bruno Otoni, Pedrosa Diego França, Eis Sérgio Ragi, Fin Irani do Carmo Francischetto, Vieira Fernando Luiz Herkenhoff, Graceli Jones Bernardes, Rangel Letícia Batista Azevedo, Silva Ian Victor
Abstract excerpt
Estrogen is a steroidal hormone involved in several physiological functions in the female body including regulation of serum lipid metabolism and breast cancer (BC). Estrogen actions on serum lipids mostly occur through its binding to intracellular Estrogen Receptor alpha (ERalpha) isoform, expressed in most of tissues. This gene (ESR1) exhibit many polymorphic sites (SNPs) located either on translated and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.