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Article

Wnt/β‐catenin pathway as a link between therapy resistance‐driven epithelial‐mesenchymal transition and stemness in colorectal cancer

20 Dec 2024

Abstract excerpt

The high plasticity of cells undergoing epithelial-mesenchymal transition (EMT) promotes increased tumor heterogeneity, and its interaction with tumor-associated stromal cells appears to contribute to developing a stemness phenotype. Cells with these characteristics exhibit increased resistance to chemotherapy and radiotherapy, leading to disease relapse and metastasis. Here, we discuss the activation of the...

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PMID: 39707719
DOI: 10.1002/cbin.12270

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