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Article

Wnt/β‑catenin signaling: Causes and treatment targets of drug resistance in colorectal cancer (Review)

1 Dec 2020

Abstract excerpt

Colorectal cancer (CRC) is the third most common malignant tumor in humans. Chemotherapy is used for the treatment of CRC. However, the effect of chemotherapy remains unsatisfactory due to drug resistance. Growing evidence has shown that the presence of highly metastatic tumor stem cells, regulation of non‑coding RNAs and the tumor microenvironment contributes to drug resistance mechanisms in CRC. Wnt/β‑catenin...

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PMID: 33300082
DOI: 10.3892/mmr.2020.11744

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