Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Acquisition of Chemoresistance and EMT Phenotype Is Linked with Activation of the Endothelin A Receptor Pathway in Ovarian Carcinoma Cells

10 Jan 2011

Abstract excerpt

PURPOSE: Emerging evidence suggests molecular and phenotypic association between chemoresistance and epithelial-mesenchymal transition (EMT) in cancer. Endothelin-1 (ET-1)/endothelin A receptor (ET(A)R) axis is implicated in the pathobiology of epithelial ovarian cancer (EOC) by driving tumor-promoting effects, including EMT. Here, we analyzed how ET(A)R regulates chemoresistance and EMT in EOC. EXPERIMENTAL...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer, Stress, Anesthesia, and Immune Response
Share to Nitric Oxide and Endothelin Effects

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21220476
DOI: 10.1158/1078-0432.ccr-10-2325

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Acquisition of Chemoresistance and EMT Phenotype Is Linked with Activation of the Endothelin A Receptor Pathway in Ovarian Carcinoma CellsPMID 21220476Read ↗

Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells.Semantic proximity Read ↗

Endothelin A Receptor/β-Arrestin Signaling to the Wnt Pathway Renders Ovarian Cancer Cells Resistant to ChemotherapySemantic proximity Read ↗

EMT transcription factors snail and slug directly contribute to cisplatin resistance in ovarian cancerSemantic proximity Read ↗

Blocking endothelin-1-receptor/β-catenin circuit sensitizes to chemotherapy in colorectal cancerSemantic proximity Read ↗

Novel oncogenic and chemoresistance-inducing functions of resistin in ovarian cancer cells require miRNAs-mediated induction of epithelial-to-mesenchymal transitionSemantic proximity Read ↗

Epithelial-to-Mesenchymal Transition in Paclitaxel-Resistant Ovarian Cancer Cells Is Downregulated by Luteolin.Semantic proximity Read ↗

hMENA is a key regulator in endothelin-1/β-arrestin1–induced invadopodial function and metastatic processSemantic proximity Read ↗

Association of the Epithelial–Mesenchymal Transition (EMT) with Cisplatin ResistanceSemantic proximity Read ↗

ZEB1 Mediates Acquired Resistance to the Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer.Semantic proximity Read ↗

TAZ overexpression is associated with epithelial-mesenchymal transition in cisplatin-resistant gastric cancer cellsSemantic proximity Read ↗

The ZEB2‐dependent EMT transcriptional programme drives therapy resistance by activating nucleotide excision repair genes ERCC1 and ERCC4 in colorectal cancerSemantic proximity Read ↗

Cisplatin-induced activation of TGF-β signaling contributes to drug resistanceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.