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Article

hMENA is a key regulator in endothelin-1/β-arrestin1–induced invadopodial function and metastatic process

8 Feb 2018

Abstract excerpt

Significance Discovering new targets and novel determinants of metastatic spread is an unmet need in ovarian cancer, which is plagued by high rates of recurrence. Endothelin-1 receptors (ET-1R), belonging to the G-protein–coupled receptor family, represent important targets critically involved in malignant progression. Here we identify a mechanistic link between ET-1R and the actin regulatory protein...

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PMID: 29439204
DOI: 10.1073/pnas.1715998115

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