Article
β-arrestin-1 is a nuclear transcriptional regulator of endothelin-1-induced β-catenin signaling.
Oncogene - 17 Oct 2013
Rosanò L, Cianfrocca R, Tocci P, Spinella F, Di Castro V, Spadaro F, Salvati E, Biroccio A M, Natali P G, Bagnato A
Abstract excerpt
Despite the fundamental pathophysiological importance of β-catenin in tumor progression, the mechanism underlying its final transcriptional output has been partially elucidated. Here, we report that β-arrestin-1 (β-arr1) is an epigenetic regulator of endothelin (ET)-1-induced β-catenin signaling in epithelial ovarian cancer (EOC). In response to ET A receptor (ETAR) activation by ET-1, β-arr1 increases its...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.