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Article

Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells.

Cancer research - 15 Dec 2005

Rosanò Laura, Spinella Francesca, Di Castro Valeriana, Nicotra Maria Rita, Dedhar Shoukat, de Herreros Antonio Garcia, Natali Pier Giorgio, Bagnato Anna

Abstract excerpt

Despite considerable efforts to improve early detection and advances in chemotherapy, metastatic relapses remain a major challenge in the management of ovarian cancer. The endothelin A receptor (ET(A)R)/endothelin-1 (ET-1) axis has been shown to have a significant role in ovarian carcinoma by promoting tumorigenesis. Here we show that the ET-1/ET(A)R autocrine pathway drives epithelial-to-mesenchymal transition...

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PMID: 16357176
DOI: 10.1158/0008-5472.CAN-05-2123

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ILK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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