Article
Translation fidelity coevolves with longevity.
Aging cell - 1 Oct 2017
Ke Zhonghe, Mallik Pramit, Johnson Adam B, Luna Facundo, Nevo Eviatar, Zhang Zhengdong D, Gladyshev Vadim N, Seluanov Andrei, Gorbunova Vera
Abstract excerpt
Whether errors in protein synthesis play a role in aging has been a subject of intense debate. It has been suggested that rare mistakes in protein synthesis in young organisms may result in errors in the protein synthesis machinery, eventually leading to an increasing cascade of errors as organisms age. Studies that followed generally failed to identify a dramatic increase in translation errors with aging....
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