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Article

Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage.

Proceedings of the National Academy of Sciences of the United States of America - 22 Oct 2013

Azpurua Jorge, Ke Zhonghe, Chen Iris X, Zhang Quanwei, Ermolenko Dmitri N, Zhang Zhengdong D, Gorbunova Vera, Seluanov Andrei

Abstract excerpt

The naked mole-rat (Heterocephalus glaber) is a subterranean eusocial rodent with a markedly long lifespan and resistance to tumorigenesis. Multiple data implicate modulation of protein translation in longevity. Here we report that 28S ribosomal RNA (rRNA) of the naked mole-rat is processed into two smaller fragments of unequal size. The two breakpoints are located in the 28S rRNA divergent region 6 and excise a...

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Identifiers

PMID: 24082110
DOI: 10.1073/pnas.1313473110
PMCID: PMC3808608

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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