Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective Deletion of Leptin Signaling in Endothelial Cells Enhances Neointima Formation and Phenocopies the Vascular Effects of Diet-Induced Obesity in Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2017

Hubert Astrid, Bochenek Magdalena L, Schütz Eva, Gogiraju Rajinikanth, Münzel Thomas, Schäfer Katrin

Abstract excerpt

OBJECTIVE: Obesity is associated with elevated circulating leptin levels and hypothalamic leptin resistance. Leptin receptors (LepRs) are expressed on endothelial cells, and leptin promotes neointima formation in a receptor-dependent manner. Our aim was to examine the importance of endothelial LepR (End.LepR) signaling during vascular remodeling and to determine whether the cardiovascular consequences of obesity...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carotid Arteries
Share to Carotid Artery Injuries

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelin-1

Share to Neointima

Share to Paracrine Communication

Share to Receptor, TIE-2

Share to Receptors, Endothelin

Share to Vascular Remodeling

Source

Identifiers

PMID: 28705795
DOI: 10.1161/ATVBAHA.117.309798

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective Deletion of Leptin Signaling in Endothelial Cells Enhances Neointima Formation and Phenocopies the Vascular Effects of Diet-Induced Obesity in Mice.PMID 28705795Read ↗

Increased atherosclerotic lesions in LDL receptor deficient mice with hematopoietic nuclear receptor Rev-erbα knock- down.Semantic proximity Read ↗

Lectin-like oxidized low-density lipoprotein receptor-1 promotes endothelial dysfunction in LDL receptor knockout background.Semantic proximity Read ↗

Leptin Induces Sca-1+ Progenitor Cell Migration Enhancing Neointimal Lesions in Vessel-Injury Mouse Models.Semantic proximity Read ↗

Reduced macrophage-dependent inflammation improves endothelin-1-induced vascular injury.Semantic proximity Read ↗

An allelic series for the leptin receptor gene generated by CRE and FLP recombinase.Semantic proximity Read ↗

Endothelial leptin receptor mutation provides partial resistance to diet-induced obesity.Semantic proximity Read ↗

Depletion of endothelial or smooth muscle cell-specific angiotensin II type 1a receptors does not influence aortic aneurysms or atherosclerosis in LDL receptor deficient mice.Semantic proximity Read ↗

Importance of leptin signaling and signal transducer and activator of transcription-3 activation in mediating the cardiac hypertrophy associated with obesity.Semantic proximity Read ↗

Leptin, the Product of Ob Gene, Promotes AngiogenesisSemantic proximity Read ↗

Effects of estrogen on the vascular injury response in estrogen receptor alpha, beta (double) knockout mice.Semantic proximity Read ↗

mTOR (Mechanistic Target of Rapamycin) Inhibition Decreases Mechanosignaling, Collagen Accumulation, and Stiffening of the Thoracic Aorta in Elastin-Deficient Mice.Semantic proximity Read ↗

Effect of endothelium-specific insulin resistance on endothelial function in vivo.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.