Article
Effects of estrogen on the vascular injury response in estrogen receptor alpha, beta (double) knockout mice.
Circulation research - 14 Sept 2001
Karas R H, Schulten H, Pare G, Aronovitz M J, Ohlsson C, Gustafsson J A, Mendelsohn M E
Abstract excerpt
The two known estrogen receptors, ERalpha and ERbeta, mediate the effects of estrogen in all target tissues, including blood vessels. We have shown previously that estrogen inhibits vascular injury response to the same extent in female wild-type (WT), ERalpha knockout (ERalphaKO(CH)), and ERbeta knockout (ERbetaKO(CH)) mice. We generated mice harboring disruptions of both ERalpha and ERbeta genes...
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