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Article

An allelic series for the leptin receptor gene generated by CRE and FLP recombinase.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Sept 2004

McMinn Julie E, Liu Shun-Mei, Dragatsis Ioannis, Dietrich Paula, Ludwig Thomas, Eiden Sandra, Chua Streamson C

Abstract excerpt

Body weight regulation is mediated through several major signaling pathways, some of which have been delineated by positional cloning of spontaneous genetic mutations in mice. Lepr(db/db) mice are obese due to a defect in the signaling portion of the leptin receptor, which has led to extensive study of this highly conserved system over the past several years. We have created an allelic series at Lepr for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15389315
DOI: 10.1007/s00335-004-2340-1

Genes

LEPR
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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