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Brief Report: Defective Early B Cell Tolerance Checkpoints in Sjögren's Syndrome Patients

13 Jul 2017

Abstract excerpt

Objective Central and peripheral B cell tolerance checkpoints are defective in many patients with autoimmune diseases, but the functionality of each discrete checkpoint has not been assessed in patients with Sjögren's syndrome (SS). We undertook this study to assess this functionality in SS patients. Methods Using a polymerase chain reaction–based approach that allows us to clone and express, in vitro,...

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PMID: 28704602
DOI: 10.1002/art.40215

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