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Article

Single-cell analysis of glandular T cell receptors in Sjögren’s syndrome

1 Jun 2016

Abstract excerpt

CD4 + T cells predominate in salivary gland (SG) inflammatory lesions in Sjögren’s syndrome (SS). However, their antigen specificity, degree of clonal expansion, and relationship to clinical disease features remain unknown. We used multiplex reverse-transcriptase PCR to amplify paired T cell receptor α (TCRα) and β transcripts of single CD4 + CD45RA – T cells from SG and peripheral blood (PB) of 10 individuals...

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PMID: 27358913
DOI: 10.1172/jci.insight.85609

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