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Article

B cells in Sjögren's syndrome: indications for disturbed selection and differentiation in ectopic lymphoid tissue

1 Jan 2007

Abstract excerpt

Primary Sjögren's syndrome (pSS) is an autoimmune disorder characterized by specific pathological features. A hallmark of pSS is B-cell hyperactivity as manifested by the production of autoantibodies, hypergammaglobulinemia, formation of ectopic lymphoid structures within the inflamed tissues, and enhanced risk of B-cell lymphoma. Changes in the distribution of peripheral B-cell subsets and differences in...

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PMID: 17697366
DOI: 10.1186/ar2210

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