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Article

Early B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production

30 Mar 2019

Abstract excerpt

Neuromyelitis optica spectrum disorders (NMOSD) constitute rare autoimmune disorders of the CNS that are primarily characterized by severe inflammation of the spinal cord and optic nerve. Approximately 75% of NMOSD patients harbour circulating pathogenic autoantibodies targeting the aquaporin-4 water channel (AQP4). The source of these autoantibodies remains unclear, but parallels between NMOSD and other...

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PMID: 31056665
DOI: 10.1093/brain/awz106

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