Article
Diminished peripheral blood memory B cells and accumulation of memory B cells in the salivary glands of patients with Sjögren's syndrome.
Arthritis and rheumatism - 1 Aug 2002
Hansen Arne, Odendahl Marcus, Reiter Karin, Jacobi Annett M, Feist Eugen, Scholze Jürgen, Burmester Gerd R, Lipsky Peter E, Dörner Thomas
Abstract excerpt
OBJECTIVE: To delineate the mechanism of the abnormalities in B cell biology found in patients with primary Sjögren's syndrome (SS). METHODS: The distribution of peripheral B cell subpopulations in 21 patients with primary SS was analyzed by immunofluorescence labeling and flow cytometry. Immunoglobulin rearrangements were analyzed in single B cells isolated from the peripheral blood and parotid glands by...
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