Article
Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Mice and Humans.
Obesity (Silver Spring, Md.) - 1 Mar 2019
Ehrhardt Nicole, Cui Jinrui, Dagdeviren Sezin, Saengnipanthkul Suchaorn, Goodridge Helen S, Kim Jason K, Lantier Louise, Guo Xiuqing, Chen Yii-Der I, Raffel Leslie J, Buchanan Thomas A, Hsueh Willa A, Rotter Jerome I, Goodarzi Mark O, Péterfy Miklós
Abstract excerpt
OBJECTIVE: Aging is associated with impaired insulin sensitivity and increased prevalence of type 2 diabetes. However, it remains unclear whether aging-associated insulin resistance is due to increased adiposity or other age-related factors. To address this question, the impact of aging on insulin sensitivity was investigated independently of changes in body composition. METHODS: Cohorts of mice aged 4 to...
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