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Article

A Cardiomyopathy Mutation in the Myosin Essential Light Chain Alters Actomyosin Structure.

Biophysical journal - 11 Jul 2017

Guhathakurta Piyali, Prochniewicz Ewa, Roopnarine Osha, Rohde John A, Thomas David D

Abstract excerpt

We have used site-directed time-resolved fluorescence resonance energy transfer to determine the effect of a pathological mutation in the human ventricular essential light chain (hVELC) of myosin, on the structural dynamics of the actin-myosin complex. The hVELC modulates the function of actomyosin, through the interaction of its N-terminal extension with actin and its C-terminal lobe with the myosin heavy chain....

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Source

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Identifiers

PMID: 28700929
DOI: 10.1016/j.bpj.2017.05.027
PMCID: PMC5510710

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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