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Article

Do cardiac actin mutations lead to altered actomyosin interactions?

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Aug 2015

Dahari Marissa, Dawson John F

Abstract excerpt

It is currently hypothesized that increased heart muscle contractility leads to hypertrophic cardiomyopathy (HCM), and reduced contractility leads to dilated cardiomyopathy (DCM). To determine if changes in the core interaction between actin and myosin occur due to mutations in the cardiac actin gene (ACTC), we measured the interactions between myosin and 8 ACTC mutant proteins found in patients with HCM or DCM....

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Identifiers

PMID: 26194323
DOI: 10.1139/bcb-2014-0156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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