Article

Cardiomyopathy Mutations Impact the Power Stroke of Human Cardiac Myosin

2020-12-09

Abstract excerpt

Cardiac muscle contraction is driven by the molecular motor myosin that uses the energy from ATP hydrolysis to generate a power stroke when interacting with actin filaments, while it is unclear how this mechanism is impaired by mutations in myosin that can lead to heart failure. We have applied a Förster resonance energy transfer (FRET) strategy to investigate structural changes in the lever arm domain of human β-...

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Literature Corpus work: 5cd95fde-0a0b-56ca-a732-ea08a2989fe1
DOI: 10.1101/2020.12.08.416511

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