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Article

Cardiomyopathy mutations impact the actin-activated power stroke of human cardiac myosin.

Biophysical journal - 1 Jun 2021

Tang Wanjian, Ge Jinghua, Unrath William C, Desetty Rohini, Yengo Christopher M

Abstract excerpt

Cardiac muscle contraction is driven by the molecular motor myosin, which uses the energy from ATP hydrolysis to generate a power stroke when interacting with actin filaments, although it is unclear how this mechanism is impaired by mutations in myosin that can lead to heart failure. We have applied a fluorescence resonance energy transfer (FRET) strategy to investigate structural changes in the lever arm domain...

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Identifiers

PMID: 33864791
DOI: 10.1016/j.bpj.2021.04.007
PMCID: PMC8390809

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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