Article
Pyrazinamide resistance-conferring mutations in pncA and the transmission of multidrug resistant TB in Georgia.
BMC infectious diseases - 12 Jul 2017
Sengstake Sarah, Bergval Indra L, Schuitema Anja R, de Beer Jessica L, Phelan Jody, de Zwaan Rina, Clark Taane G, van Soolingen Dick, Anthony Richard M
Abstract excerpt
BACKGROUND: The ongoing epidemic of multidrug-resistant tuberculosis (MDR-TB) in Georgia highlights the need for more effective control strategies. A new regimen to treat MDR-TB that includes pyrazinamide (PZA) is currently being evaluated and PZA resistance status will largely influence the success of current and future treatment strategies. PZA susceptibility testing was not routinely performed at the National...
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