Article

The Alexander Disease Protein GFAP Drives Mitochondrial Fission

2024-02-21

Abstract excerpt

Mitochondrial plasticity, coordinated by fission and fusion, is crucial to ensure cellular functions. Mitochondrial fission is mediated by the GTPase Drp1 at the constriction site, which is proposed to be driven by the actin-myosin contractile force. However, the mechanism that propels constriction remains unclear, and the potential involvement of additional mechanisms in this process remains an open question. Her...

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Literature Corpus work: 11da4182-027b-51e9-b8eb-68c945a923fb
DOI: 10.1101/2024.02.20.581117

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