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Article

A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma.

Nature genetics - 1 Apr 2014

Yoo Hae Yong, Sung Min Kyung, Lee Seung Ho, Kim Sangok, Lee Haeseung, Park Seongjin, Kim Sang Cheol, Lee Byungwook, Rho Kyoohyoung, Lee Jong-Eun, Cho Kwang-Hwi, Kim Wankyu, Ju Hyunjung, Kim Jaesang, Kim Seok Jin, Kim Won Seog, Lee Sanghyuk, Ko Young Hyeh

Abstract excerpt

The molecular mechanisms underlying angioimmunoblastic T cell lymphoma (AITL), a common type of mature T cell lymphoma of poor prognosis, are largely unknown. Here we report a frequent somatic mutation in RHOA (encoding p.Gly17Val) using exome and transcriptome sequencing of samples from individuals with AITL. Further examination of the RHOA mutation encoding p.Gly17Val in 239 lymphoma samples showed that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24584070
DOI: 10.1038/ng.2916

Genes

RHOA

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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A recurrent inactivating mutation in RHOA GTPase in angioimmunoblastic T cell lymphoma.PMID 24584070Read ↗

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