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A Survey of Somatic Mutations in 41 Genes in a Cohort of T-Cell Lymphomas Identifies Frequent Mutations in Genes Involved in Epigenetic Modification.

Applied immunohistochemistry & molecular morphology : AIMM - 1 Jul 2019

Fernandez-Pol Sebastian, Ma Lisa, Joshi Rohan P, Arber Daniel A

Abstract excerpt

Here, we utilize a high throughput sequencing panel that covers several genes known to be recurrently mutated in certain T-cell lymphoma subtypes as well as genes frequently mutated in other hematolymphoid malignancies, including myeloid neoplasms. This panel was applied to formalin-fixed, paraffin-embedded tissue from 84 biopsies from 78 patients selected for this study. The biopsies included ones a with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29629950
DOI: 10.1097/PAI.0000000000000644

Genes

RHOA
TET2

Variants

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